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Culture Club Msg Board > Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis
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May 18, 2026
1:23 AM 		Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective degeneration of upper and lower motor neurons, leading to muscle denervation and respiratory failure. Unlike Alzheimer's disease (AD) or Parkinson's disease (PD), ALS pathology is driven by TDP-43 proteinopathy, C9orf72 repeat expansions, and non-cell autonomous toxicity from glial cells.


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