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This recombinant human collagen type I / COL1 is available as full-chain or single chain molecules. Its synthesis and assembly require a multitude of genes and post-translational modifications which gives a more native human structure. The triple-helical collagens made by recombinant technology have the same amino acid sequence as human tissue-derived collagen. Furthermore, by achieving the equivalent extent of proline hydroxylation via co-expression of genes encoding prolyl hydroxylase with the collagen genes, one can produce collagens with a similar degree of stability as naturally occurring material.